Selected publications EthoVision

On this page you will find a number of publications in which EthoVision was used, ordered by test paradigm. 

• Optogenetics
• Morris water maze
• Novel object recognition 
• Open field 
• Elevated plus maze
• Social interaction
• Barnes maze
• Social/shoaling behavior (zebrafish)
• Novel tank diving (zebrafish)
• T-maze (zebrafish)
• Other applications

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Optogenetics

• Durieux, P.F.; Schiffmann, S.N.; de Kerchove d'Exaerde, A. (2012). Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions. The EMBO Journal, 31, 640-653.
• Kravitz, A.V.; Freeze, B.S.; Parker, P.R.L.; Kay, K.; Thwin, M.T.; Deisseroth, K.; Kreitzer, A.C. (2010). Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature, 466, 622-626.
• Kravitz, A.V.; Tye, L.D.; Kreitzer, A.C. (2012). Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nature Neuroscience, 15, 816-818.
• Stamatakis,  A.M.; Stuber, G.D. (2012). Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nature Neuroscience, 15(8), 1105-1107.
• Kim, K.M.; Baratta, M.V.; Yang, A.; Lee, D.; Boyden, E.S.; Fiorillo, C.D. (2012). Optogenetic mimicry of the transient activation of dopamine neurons by natural reward is sufficient for operant reinforcement. PLOS ONE, 7(4), e33612.

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Morris water maze

• Nishimura, M.; Gu, X.; Swann, J.W. (2011). Seizures in early life suppress hippocampal dendrite growth while impairing spatial learning. Neurobiology of Disease, 44 (2), 205-214.
• Zheng, Y.; Hamilton E.; Begum, S.; Smith, P.F.; Darlington, C.L. (2011). The effects of acoustic trauma that can cause tinnitus on spatial performance in rats. Neuroscience, 186, 48-56.
• Oyagi, A.; Moriguchi, S.; Nitta, A.; Murata, K.; Oida, Y.; Tsuruma, K.; Shimazawa, M.; Fukunaga, K.; Hara, H. (2011). Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation. Brain Research, 1419, 97-104.
• Sartori, C. R.; Vieira, A. S.; Ferrari, E.M.; Langone, F.; Tongiorgi, E.; Parada, C.A. (2011). The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related, p11 and tPA. Neuroscience, 180, 9-18.
• Chang, W. P.; Huang X. P.; Downs, D.; Cirrito, J.R.; Koelsch, G.; Holtzman, D.M.; Ghosh, A.K.; Tang, J. (2011)."beta-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice." Faseb Journal, 25 (2), 775-784.
• Kim, M. E.; Park, H. R.; Gong, E.J.; Choi, S.Y.; Kim, H.S.; Lee, J. (2011). Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Food and chemical toxicology, 49 (12), 3383-3389.
• VanGuilder, H. D.; Farley, J. A.; Yan, H.; Kirk, van, C.A.; Mitschelen, M.; Sonntag, W.E.; Freeman, W.M. (2011). Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiology of Disease, 43 (1), 201-212.
• Maeda, T.; Maeda, A.; Casadesus, G.; Palczewski, K.; Margaron, P. (2009). Evaluation of 9-cis-Retinyl Acetate Therapy in Rpe65-/- Mice. Investigative Ophthalmology & Visual Science, 50 (9), 4368-4378.
• Mitschelen, M.; Garteiser, P.; Carnes, B.A.; Farley, J.A.; Doblas, S.; Demoe, J.H.; Warrington, J.P.; Yan, H.; Nicolle, M.M.; Towner, R.; Sonntag, W.E. (2009). Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impariment in aging rodents. Neuroscience, 164 (3), 918-928.
• Taylor, G.A.; Rodriguiz, R.M.; Greene, R.I.; Daniell. X.; Henry, S.C.; Crooks, K.R.; Kotloski, R.; Tessarollo, L.; Philips, L.E.; Wetsel, W.C. (2008). Behavioral characterization of P311 knockout mice. Genes, Brain and Behavior, 7, 786-795.
• Chevere-Torres, I.; Maki, J.M.; Santini, E.; Klann, E. (2012). Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin. Neurobiology of Disease, 45 (1), 156-164.

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Novel object recognition

• Benice, T.J.; Raber, J.  (2008). Object recognition analysis in mice using nose-point digital video tracking. Journal of Neuroscience Methods, 168, 422-430.
• Chambon, C.; Wegener, N.; Gravius, A.; Danysz, W. (2011). A new automated method to assess the rat recognition memory: Validation of the method. Behavioural Brain Research, 222, 151-157.
• Chevere-Torres, I.; Maki, J.M.; Santini, E.; Klann, E. (2012). Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin. Neurobiology of Disease, 45 (1), 156-164.
• Cyrenne, D.M.; Brown, G.R. (2011). Effects of suppressing gonadal hormones on response to novel objects in adolescent rats. Hormones and Behavior, 60, 625-631.
• Eiland, L.; McEwan, B.S. (2012). Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus, 22, 82-91.
• Grauer, S.M.; Pulito, V.L.; Navarra, R.L.; Kelly, M.P.; Kelley, C.; Graf, R.; Langen, B.; Logue, S.; Brennan, J.; Jiang, L.; Charych, E.; Egerland, U.; Liu, F.; Marquis, K.L.; Malamas, M.; Hage, T.; Comery, T.A.; Brandon, N.J. (2009). Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. The Journal of Pharmacology and Experimental Therapeutics, 331, 574-590.
• Haydar, S.N.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.A.; Dunlop, J.; La Rosa, S.;  Micco, I.; Pollastrini, M.; Quinn, J.; Roncarati, R.; Scali, C.; Valacchi, M.; Varrone, M.; Zanaletti, R. (2009). SAR and biological evaluation of  SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist. Bioorganic & Medicinal Chemistry, 17, 5247-5258.
• Marquis, K.L.; Comery, T.A.; Jow, F.; Navarra, R.L.; Grauer, S.M.; Pulicicchio, C.; Kelley, C.; Brennan, J.A.; Roncarati, R.; Scali, C.; Haydar, S.;  Ghiron, C.; Terstappen, G.C.; Dunlop, J. (2011). Preclinical assessment of an adjunctive treatment approach of cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625. Psychopharmacology, 218, 635-647.
• McDowell, K.A.; Hutchinson, A.N.; Wong-Goodrich, S.J.E.; Presby, M.M.; Su, D.; Rodriguiz, R.M.; Law, K.C.; Williams, C.L.; Wetsel, W.C.; West, A.E. (2010). Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. The Journal of Neuroscience, 30 (22), 7453-7465.
• Roncarati, R.; Scali, C.; Comery, T.A.; Grauer, S.M.; Aschmi, S.; Bothmann, H.; Jow. B.; Kowal, D.; Gianfriddo, M.; Kelley, C.; Zanelli, U.; Ghiron, C.; Haydar, S.; Dunlop, J.; Terstappen, G.C. (2009). Procognitive and neuroprotective activity of a novel α7 nocotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. The Journal of Pharmacology and Experimental Therapeutics, 329, 459-468.
• Siegel, J.A.; Park, B.S.; Raber, J. (2011). Long-term effects of neonatal methamphetamine exposure on cognitive function in adolescent mice. Behavioural Brain Research, 219, 159-164.
• Simmons, D.A.; Rex, C.S.; Palmer, L.; Pandyarajan, V.; Fedulov, V.; Gall, C.M.; Lynch, G. (2009). Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proceedings of the National Academy of Sciences, 106, 4906-4911.
• Sydserff, S.; Sutton, E.J.; Song, D.; Quirk, M.C.; Maciag, C.; Li, C.; Jonak, G.; Gurley, D.; Gordon, J.C.; Christian, E.P.; Doherty, J.J.; Hudzik, T.; Johnson, E.; Mrzljak, L.; Piser, T.; Smagin, G.N.; Wang, Y.; Widzowski, D.; Smith, J.S. (2009). Selective a7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochemical Pharmacology, 78, 880-888.
• Tereshchenko, Y.; Brandewiede, J.; Schachner, M.; Irintchev, A.; Morellini, F. (2008). Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice. Behavioural Brain Research, 191, 280-284.

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Open field

• Oliver, P.; Davies, K.E. (2009). Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. HMG Advanced Access.
• Tereshchenko, Y.; Brandewiede, J.; Schachner, M.; Irintchev, A.; Morellini, F. (2008). Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice. Behavioural Brain Research, 191, 280-284.
• Devall, A.J.; Liu, Z. W.; Lovick, T.A. (2009). Hyperalgesia in the setting of anxiety: Sex differences and effects of the oestrous cycle in Wistar rats. Psychoneuroendocrinology, 34, 587-596.
• Garcia-Garcia, A.L.; Elizalde, N.; Matrov, D.; Harro, J.; Wojcik, S.M.; Venzala, E.; Ramfrez, M.J.; Del Rio, J.; Tordera, R.M. (2009). Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1. Society of Biological Psychiatry, 66, 275-282.
• Kakefuda, KI.; Fujita, Y.; Oyagi, A.; Hyakkoku, K.; Kojima, T.; Umemura, K.; Tsuruma, K.; Shimazawa, M.; Ito, M.; Nozawa, Y.; Hara, H. (2009). Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochemical and Biophysical Research Communications, 387, 784-788.

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Elevated plus maze

• Oliver, P.; Davies, K.E. (2009). Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. HMG Advanced Access.
• Tereshchenko, Y.; Brandewiede, J.; Schachner, M.; Irintchev, A.; Morellini, F. (2008). Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice. Behavioural Brain Research, 191, 280-284.

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Social interaction

• Chevere-Torres, I.; Maki, J.M.; Santini, E.; Klann, E. (2012). Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin. Neurobiology of Disease, 45 (1), 156-164.

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Barnes maze

• Hao, W.; Liu, Y.; Liu, S.; Walter, S.; Grimm, M.O.; Kiliaan, A.J.; Penke, B.; Hartmann, T.; Rübe, C.E.; Menger, M.d.; Fassbender, K. (2011). Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer’s disease-related symptoms and pathology. Brain, 134, 278-292.

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Social behavior and shoaling (zebrafish)

• Green, J.; Collins, C.; Davis, A.; Kyzar, E.; Pham, M; El-Ounsi, M.; Roth, A.; Gaikwad, S.; Lansdman, S.; Cachat, J.; Grieco, F.; Tegelenbosch, R.; Noldus, L.; Kalueff, A.V. (2012). Towards automated highthroughput neurophenotyping of zebrafish social (shoaling) behavior. Society for Neuroscience SfN-2012 Abstract book, New Orleans, USA.
• Grossman, L.; Utterback, E.; Stewart, A.; Gaikwad, S.; Chung, K.M.; Suciu, C.; Wong, K.; Elegante, M.; Elkhayat, S.; Tan, J.; Gilder, T.; Wu, N.; DiLeo, J.; Kalueff, A.V. (2010). Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research, 214, 277-284. 
• Kalueff, A.V.; Schmidt, M.V. (2011) Novel experimental models and paradigms for neuropsychiatric disorders: editorial. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 1355-1356.
• Kyzar, E.J.; Collins, C.; Gaikwad, S.; Green, J.; Roth, A.; Monnig, L.; El-Ounsi, M.; Davis, A.; Freeman, A.; Capezio, N.; Steward, A.M.; Kalueff, A.V. (2012) Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 37 (1), 194-202.

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Novel tank diving test zebrafish

• Bencan, Z.; Damiyon, S.; Levin, E.D. (2009). Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacology, Biochemistry and Behavior, 94, 75-80.
• Blaser, R.E.; Goldsteinholm, K. (2012). Depth preference in zebrafish, Danio rerio: control by surface and substrate cues. Animal Behaviour, 83 (4), 953-959.
• Cachat, J.M.; Canavello, P.R.; Elegante, M.F.; Bartels, B.K.; Elkhayat, S.I.; Hart, P.C.; Tien, A.K.; Tien, D.H.; Beeson, E.C.; Mohnot, S.; Laffoon, A.L.;Stewart, A.M.; Gaikwad, S.; Wong, K.; Haymore, W.; Kalueff, A.V. (2011). Modeling stress and anxiety in zebrafish. Chapter 3 from Zebrafish Models in Neurobehavioral Research, Neuromethods, 52, Humana Press, NY, ISBN 978-1-60761-921-5.
• Cachat, J.M.; Canavello, P.R.; Elkhayat, S.I.; Bartels, B.K.; Hart, P.C.; Elegante, M.F.; Beeson, E.C.; Laffoon, A.L.; Haymore, W.A.M.; Tien, D.H.; Tien, A.K.; Mohnot, S.; Kalueff, A.V. (2011). Video-aided analysis of zebrafish locomotion and anxiety-related behavioral responses. Chapter 1 from Zebrafish Neurobehavioral Protocols, Neuromethods, Spinger Science+Business Media, ISBN 978-1-60761-952-9. 
• Cachat, J.; Stewart, A.; Utterback, E.; Hart, P.; Gaikwad, S.; Wong, K.; Kyzar, E.; Wu, N.; Kalueff, A.V. (2011). Three-dimensional neurophenotyping of adult zebrafish behavior. PLoS ONE, 6 (3), e17597. 
• Canavello, P.R.; Cachat, J.M.; Elkhayat, S.I.; Bartels, B.K.; Hart, P.C.; Elegante M.F.; Beeson, E.C.; Laffoon, A.L.; Haymore, W.A.M.; Tien, D.H.; Tien, A.K.; Mohnot, S.; Kalueff, A.V. (2011). Video-aided analysis of zebrafish locomotion and anxiety-related behavioral responses. Neuromethods, 51, 1-14.
• Champagne, D.L.; Hoefnagels, C.C.M.; de Kloet, R.E.; Richardson, M.L. (2010). Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research. Behavioural Brain Research, 214, 332-342.
• Grossman, L.; Utterback, E.; Stewart, A.; Gaikwad, S.; Chung, K.M.; Suciu, C.; Wong, K.; Elegante, M.; Elkhayat, S.; Tan, J.; Gilder, T.; Wu, N.; DiLeo, J.; Cachat, J.; Kalueff, A.V. (2010). Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research, 214, 277-284.
• Kyzar, E.J.; Collins, C.; Gaikwad, S.; Green, J.; Roth, A.; Monnig, L.; El-Ounsi, M.; Davis, A.; Freeman, A.; Capezio, N.; Stewart, A.M.; Kalueff, A.V. (2012). Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 37, 194-202.
• Levin, E. (2011). Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. Reviews in the Neurosciences, 22 (1), 75-84. 
• Stewart, A.; Wu, N.; Cachat, J.; Hart, P.; Gaikwad, S.; Wong, K.; Utterback, E.; Gilder, T.; Kyzar, E.; Newman, A.; Carlos, D.; Chang, K.; Hook, M.; Rhymes, K.; Caffery, M.; Greenberg, M.; Zadina, J.; Kalueff, A.V. (2011). Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 1421-1431. 
• Williams, L.R.; Wong, K.; Stewart, A.; Suciu, C.; Gaikwad, S.; Wu, N.; DiLeo, J.; Grossman, L.; Cachat, J.; Hart, P.; Kalueff, A.V. (2012). Behavioral and physiological effects of RDX on adult zebrafish. Comparative Biochemistry and Physiology, Part C, 155, 33-38.

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T-maze zebrafish

• Grossman, L.; Utterback, E.; Stewart, A.; Gaikwad, S.; Chung, K.M.; Suciu, C.; Wong, K.; Elegante, M.; Elkhayat, S.; Tan, J.; Gilder, T.; Wu, N.; DiLeo, J.; Chachat, J.; Kalueff, A.V. (2010). Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research, 214, 277-284.
• Peitsaro, N.; Kaslin, J.; Anichtchik, O.V.; Panula, P. (2003). Modulation of the histaminergic system and behavior by α-fluoromethylhistidine in zebrafish. Journal of Neurochemistry, 86, 432-441. 
• Saili, K.S.; Corvi, M.M.; Weber, D.N.; Patel, A.U.; Das, S.R.; Przybyla, J.; Anderson, K.A.; Tanguay, R.L. (2012). Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology, 291, 83-92.

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Other applications

• Battaglia, F.P.; Kalenschera, T.; Cabral, H.; Winkel, J.; Bosa, J.; Manuputy, R.; Lieshout, T. van;  Pinkseb, F.; Beukers, H.; Pennartza, C. (2009). The Lantern: An ultra-light micro-drive for multi-tetrode recordings in mice and other small animals. Journal of Neuroscience Methods, 178, 291-300.
• Fonio, E.; Benjamin, Y.; Golani, I. (2009). Freedom of movement and the stability of its unfolding in free exploration of mice. PNAS, 106 (50), 21335-21340.
• Mao, Y.; Ge, X.; Frank, C.L.; Madison, J.M.; Koehler, A.N.; Doud, M.K.; Tassa, C.; Berry, E.M.; Soda, T.; Singh, K.K.; Biechele, T.; Petryshen, T.L.; Moon, R.T.; Haggarty, S.J.; Tsai, L.H. (2009). Disrupted in Schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3B/B-Catenin signaling. Cell, 136, 1017-1031.
• Venerosi, A.; Cutuli, D.; Colonnello, V.; Cardona, D.; Ricceri, L.; Calamandrei, G. (2008). Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood. Neurotoxicology and Teratology, 30, 468-474.

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