Operant conditioning

Operant conditioning is a learning test used in animal studies to either reinforce or diminish (extinct) certain behaviors. For example, you can teach a mouse to press a lever to receive a food reward, or a fish to stay away from a certain area to avoid a negative stimulus such as a shock or bright light.

Automate operant conditioning tasks

The whole process of an operant conditioning experiment can easily be automated with EthoVision XT. In the software, you can set-up a program so that EthoVision XT detects certain behaviors of your animal, and in turn sends out a signal to turn certain stimuli on or off. For example: The animal enters a specific area in its cage, this is detected by EthoVision XT, in turn sending out a signal to the pellet dispenser, so that the animal receives its award. Read more about it here.

Mouse

Test EthoVision XT yourself

Request a FREE trial and find out what EthoVision XT can do for your research!

  • Automatically track any animal in any arena
  • Integrate physiology and control of equipment such as doors and stimuli
  • Build a platform to exactly suit your research needs

Operant conditioning in the home cage

In most cases, animals are transported from their home cage to a testing area. Handling of the animal and the novel environment both cause stress, which can influence your test results. Therefore, testing in the home cage has become increasingly popular.

PhenoTyper is extremely suitable to carry out operant conditioning tasks in the home cage. It can be adapted to fit many different experimental setups, and as such be fitted with levers, lights, a pellet dispenser, running wheel, speaker for audio signals, and so on. It also benefits from the easy automation of the test with EthoVision XT, as described above. Read more about operant conditioning in the home cage.

Operant conditioning in the home tank

The benefits of testing in the home environment also offer opportunities for fish. We are currently developing a home cage system for operant conditioning of zebrafish. View the prototype here.

Operant conditioning and optogenetics

Following the example above, you can give an animal a food reward, but you can also directly stimulate the dopamine receptors in the brain to reward the animal. That is what Dr. Kravitz and Dr. Kreitzer did. Read more about it on our blog.