Zebrafish larvae activity
Rob Willemsen and Herma van der Linde (Erasmus MC Rotterdam, The Netherlands)
Our research focuses on the leucine-rich repeat kinase 2 (LRRK2) gene. Mutations in the LRRK2 gene are the most frequent known cause of PD. The major aim of our research is understanding the molecular mechanisms underlying PD by generating animal models of PD using zebrafish, Danio rerio. Further characterization of these genetically modified zebrafish includes swimming behavior as a readout for aberrant motor activity. Larval zebrafish represent an excellent model to study locomotive behavior. Zebrafish larvae show a robust locomotor activity, such as swimming, at day 6-7 post fertilization (dpf).
In the present study we used DanioVision™ an automated high-throughput tracking system of zebrafish larvae from Noldus Information Technology (Wageningen, the Netherlands), including control of light and dark conditions, to study the effect of several doses of dopamine on locomotor activity of wild type larvae of zebrafish.
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