Quantification of seizure activity: The Observer supports research in epilepsy.
D. Jonker, M. Danhof and R.A. Voskuyl (Leiden, The Netherlands).
Seizures are defined as transient changes of behavior due to inappropriate, synchronous and rhythmic firing of central nervous system neurons. The literature provides detailed descriptions of the symptoms of seizures, but these observations are not quantified. Quantitative estimation is important for the measurement of the effects of anti-epileptic drugs.
In this report, The Observer was used to count the occurrence of seizure components in rats with different types of electrical induced seizures. In addition, the relation between drug concentration and suppression of these seizure components was estimated for several anti-epileptic drugs.
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