ErasmusLadder references

This is a selection of publications that mention the use of ErasmusLadder. If you feel your publication should be on this list, please let us know at


Seungmin Ha, Dongwon Lee, Yi Sul Cho, Changuk Chung, Ye-Eun Yoo, Jihye Kim, Jiseok Lee, Woohyun Kim, Hyosang Kim, Yong Chul Bae, Keiko Tanaka-Yamamoto and Eunjoon Kim (2016). Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors, Journal of Neuroscience, 36 (48),12129-12143.

Peter, S.; ten Brinke, M.M.; Stedehouder, J.; Reinelt, C.M.; Wu, B.; Zhou, H.; Zhou, K.; Boele, H.; Kushner, S.A.; Lee, M.G.; Schmeisser, M.J.; Boeckers, T.M.; Schonewille, M.; Hoebeek, F.E.; De Zeeuw, C.I. (2016). Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice. Nature Communications, 7, 12627.


De Zeeuw, C.I.; Hoogland, T.M. (2015) Reappraisal of Bergmann glial cells as modulators of cerebellar circuit functionFrontiers in Cellular Neuroscience, doi 10.3389/fncel.2015.00246

Marques, A.R.A.; Aten, J.; Ottenhoff, R. van; Roomen, C.P.A.A.; Herrera Moro, D.; Claessen, N.; Vinueza Veloz, M.F.; Zhou, K.; Lin, Z.; Mirzaian, M.; Boot, R.G.; De Zeeuw, C.I.; Overkleeft, H.S.; Yildiz, Y.; Aerts, J.M.F.G. (2015) Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice. PLoS ONE, 10(8): e0135889. doi:10.1371/journal.pone.0135889

Vinueza Veloz, M.F. (2015). Cerebellar control of locomotion in health and disease. Erasmus University Rotterdam. Retrieved from


Sepulveda-Falla, D.; Barrera-Ocampo, A.; Hagel, C.; Korwitz, A.; Vinueza-Veloz, M.F.; Zhou, K.; Schonewille, M.; Zhou, H.; Velazquez-Perez, L.; Rodriguez-Labrada, R.; Villegas, A.; Ferrer, I.; Lopera, F.; Langer, T.; De Zeeuw, C.I.; Glatzel, M. (2014). Familial Alzheimer's disease-associated presenilin-1 alter cerebellar activity and calcium homeostasisThe Journal of Clinical Investigation124(4), 1552-1567.

Vinueza Veloz, M.F.; Zhou, K.; Bosman, L.W.J.; Potters, J.-W.; Negrello, M.; Seepers, R.M.; Strydis, C.; Koekkoek, S.K.E.; De Zeeuw, C.I. (2014). Cerebellar control of gait and interlimb coordinationBrain Structure and Function, doi: 10.1007/s00429-014-0870-1. Read about this study on our behavioral research blog

Earlier publications

Baudouin, S.J.; Gaudias, J.; Gerharz, S.; Hatstatt, L.; Zhou, K.; Punnakkal, P.; Tanaka, K.F.; Spooren, W.; Hen, R.; De Zeeuws, C.I.; Vogt, K.; Scheiffele, P. (2012) Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autismScience338, 128-132.

Boele, C.P., Roelofs R., Koekkoek SKE & De Zeeuw C.(2013) Automated assessment of motor learning and motor performance using the Erasmus Ladder - a new method for phenotyping of mouse mutants. Poster, IBANGS conference 2013.

Cupido, A. (2009). The Erasmus Ladder: a new, automated system for precise phenotyping of motor behavior in mice. PhD Thesis, Erasmus University Rotterdam (Chapter 2). 

Galliano, E.; Gao, Z.; Schonewille, M.; Todorov, B.; Simons, E.; Pop, A.S.; D’Angelo, E.; Maagenberg, A.M.J.M.; Hoebeek, F.E.; De Zeeuw, C. (2013). Silencing the Majority of Cerebellar Granule Cells Uncovers Their Essential Role in Motor Learning and Consolidation. Cell Reports, 3, 1239-1251.

Saab, A.S.; Neumeyer, A.; Jahn, H.M.; Cupido, A.; Simek, A.A.M.; Boele, H.-J.; Scheller, A.; Le Meur, K.; Götz, M.; Monyer, H.; Sprengel, R.; Rubio, M.E.; Deitmer, J.W., De Zeeuw, C.I.; Kirchhoff, F. (2012) Bergmann glial AMPA receptors are required for fine motor coordination. Science337, 749-753.

Schonewille, M.; Gao, Z.; Boele, H.-J.; Vinueza Veloz, M.F.; Amerika, W.E.; Simek, A.A.M.; De Jeu, M.T.; Steinberg, J.P.; Takamiya, K.; Hoebeek, F.E.; Linden, D.J.; Huganir, R.L.; De Zeeuw, C.I. (2011). Reevaluating the Role of LTD in Cerebellar Motor Learning. Neuron, 70, 43-50.

Venueza Veloz, M.F.; Buijsen, R.A.M.; Willemsen, R.; Cupido, A.; Bosman, L.W.J.; Koekkoek, S.K.E.; Potters, J.W.; Oostra, B.A.; De Zeeuws, C.I. (2012) The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice. Genes, Brain and Behavior, 11, 325–331.