Noldus USB-IO box

The Noldus USB-IO box is a device that enables EthoVision XT to communicate directly with external equipment. You can use it to connect to the Noldus pellet dispenser, the Noldus lickometer, levers, or the light and sound stimuli of a PhenoTyper topunit. You can also use it to connect to the automated parts of mazes and other test set-ups, such as automatic doors. When you combine the easy-to-use programming environment of EthoVision XT’s Trial & Hardware Control Module with the USB-IO box, your research can become fully automated. 


  • Use an easy and cost-effective tool to build a fully automated set-up in combination with EthoVision XT.
  • Combine different kinds of equipment that send and receive signals or data to and from the USB-IO box or the mini USB-IO box.


The USB-IO box provides the interface between EthoVision XT’s Trial & Hardware Control module and peripheral devices. It allows you to benefit from all the different options for completely automated set-ups that EthoVision XT offers. This even includes set-ups with multiple cages and multiple animals per cage, even in synchrony with external physiological signals.


You can use the USB-IO box in a wide variety of set-ups, connecting any kind of standard TTL (Transistor-Transistor Logic) based equipment. This makes it a very cost-effective and efficient tool; you can use new equipment, equipment that is already in you lab, or custom made devices. You can also choose the box that suits your requirements: the USB-IO box or the mini USB-IO box.

Connect your devices

The USB-IO box is capable of receiving signals or data from devices as well as sending signals or data to the device. It is the ideal tool to connect PhenoTyper to accessories such as the pellet dispenser and lickometer. The USB-IO box contains twelve TTL connections, each connection supporting two TTL in and two TTL outlines in order to receive and send multiple signals to and from a device such as the pellet dispenser. The USB-IO box also contains thirteen SDI (Special Device Interface) connections to send and receive data to and from devices such as the lickometer. Furthermore, each SDI connection is capable of controlling up to four PhenoTyper top-units.

Mini USB-IO box

The mini version of the USB-IO box has fewer connections and provides a low-cost solution for your research. It contains four TTL connections, one SDI, and a TTL expansion port to connect up to sixteen additional TTL output lines. The mini USB-IO box is ideally used to control on-demand water maze platforms, automatic guillotine doors (in a radial arm maze, or a T- or Y-maze), pellet dispensers, shocker floors, or any other TTL-based hardware

Mini IO-box
The mini USB-IO box is a low-cost solution with fewer connections. 
TTL 28v converter
This converter allows you to control atuomated doors of a T-maze or radial arm maze. 

TTL to 28 Volt converter for Med Associates equipment

Med Associates equipment, such as the automated doors of a T-maze or radial arm maze, requires  28 Volt to operate. To makes things easy, Noldus designed a TTL to 28 Volt converter; a plug and play device that allows you to connect one or two Med Associates devices to the USB-IO box, or the mini USB-IO box. You can daisy-chain multiple TTL to 28 Volt converters. A cost-effective solution for a completely integrated system! 

Technical specifications 

  Noldus USB-IO box Noldus mini USB-IO box TTL to 28 Volt converter
Power Requirements 24 V DC 24 V DC 28 V DC external power supply
Current consumption Max. 2A (depends on devices connected) Max. 1A (depends on devices connected) 40mA (without device connected)
  • 12 TTL control connections representing 24 TTL output lines and 24 TTL input lines
  • 12 Special Device Interface connections
  • 4 TTL control connections representing 8 TTL output lines en 8 TTL input lines
  • 1 Special Device Interface connection
  • 1 TTL expansion port for 16 TTL output lines
  • 2 28V output connections
  • 1 (mini) USB-IO box input connection
Dimensions 16.0 x 16.0 x 9.0 cm (6.3" x 6.3" x 3.6") 8.1 x 17.5 x 3.0 cm (3.2" x 6.9" x 1.2")  
Power supply 24 V, 3 A DC with main cable (EU or US type) 24 V, 3 A DC with main cable (EU or US type)  
Cable to PC USB A/B cable USB A/B cable