Tools for

Learning and memory tests in zebrafish

The learning capabilities of zebrafish have been well-characterized in research. Many paradigms used in rodent studies, such as those using mazes, have been successfully adapted to zebrafish studies. They have been proven useful to study the effects of genetic disposition, chemical alterations, substances of abuse (such as alcohol), and promising substances in the treatment of specific disorders.

However, keeping track of zebrafish behavior can be a challenge because of their fast and often erratic movement.

Tools for Learning and memory tests in zebrafish
 

T-maze testing

The T-maze, or variations such as the Y-maze and cross-maze, is well-validated for discriminative learning tasks. The fish learn to select a certain zone to swim to based on natural preference for the environment (color, water depth, enrichment) or certain stimuli. Taught to expect a certain reward, fish will normally learn this quite easily.

t maze setup
 


Free white paper

Zebrafish and learning paradigms

Zebrafish have become an important animal model for studying neurodegenerative diseases. In validation of these models, both pathologically and behaviorally, many standardized paradigms have been translated from rodent models to zebrafish.

Download the white paper and learn more about zebrafish and learning paradigms.

 


Advantages of using software

Latency to reach the ‘goal areas’ is an obvious parameter in learning studies, and can even be measured manually quite easily. The same is true for the amount of entries to or transitions between zones, and the relative amount of time spent in a certain zone. However, additional valuable parameters such as swimming velocity and path shape may not be measured as easily. All provide valuable information about the learning and memory capabilities of the fish and how these capabilities are influenced by genetics or drugs. Video tracking makes this an easy job, giving consistent and objective measurements for reliable data.

 


css ruud van den bos zebrafish daniovision ethovision screenshot software

EthoVision XT

EthoVision XT is a video tracking software platform to build your experiments on, and serves as a versatile and scalable solution at the core of your lab. It is easy to use, and over 2000 sites use and publish with it.

Video tracking data contains abundant information, and a large set of data selection options and parameters is at your disposal to get you the measurements you need EthoVision XT also offers a platform for fully integrated setups.

 
 


Relevant blogs

dive-into-zebrafish-research

Don’t dwell on it… dive into zebrafish research!

I recently wrote about other translations from rodent studies to zebrafish, such as the investigation of learning and memory and social behavior. Now it’s time to talk about anxiety and exploration.
behavioral-assays-zebrafish-drug-screening

Behavioral assays establish zebrafish in drug screening

Zebrafish are increasingly swimming into the view of large-scale drug screening projects. Behavioral screens can be used as a first-line detection tool for new drug effects, and their popularity continues to grow.
zebrafish-neurodegenerative-diseases

Zebrafish help us to understand neurodegenerative and neuromuscular diseases

Teresa Capriello and colleagues use zebrafish to study the neuronal mechanisms of heavy metals in connection to neurodegenerative and neuromuscular diseases.
 
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