Most humans can tell you they’re in pain. However, assessing pain sensitivity in rodents during preclinical studies is a challenge.
There is an unmet medical need to develop clinical effective treatments for Leigh Syndrome and other mitochondrial diseases. Today, Dr. de Haas shares some of her research insights.
CatWalk XT system
Our lab studies the Neuronal Ceroid Lipofuscinoses (NCLs) or Batten disease, which are a group of progressive and genetically inherited neurodegenerative diseases that affect children and young adults.
Contrary to common methods, gait analysis can detect clinically relevant symptoms early on, researchers say.
mouse gait study
At the Dr. Michael Fehlings' lab, they are on a quest to find out what exactly causes the lower success rate of delayed surgery in cervical myelopathy.
Catwalk XT
Heta Svard from Orion Pharma studies pain and neurological disorders and resports on recent research.
CatWalk XT
Letting animals walk freely in gait research. At Noldus, we strongly believe this is the way to go, so that is how our CatWalk XT system works.
Rat in CatWalk
Traditionally, there are two fundamentally different ways to analyze gait in animals. One can either observe or measure gait in an unrestricted manner, or in a forced manner, as seen when using a treadmill or treadwheel.
Walking rat
I have written two blogs about static gait parameters. Now it’s time to talk about all four paws, and the time based relationships between them. If you ask me, we’ve been saving the best blog for last!
Rat on CatWalk XT runway
A footprint, that is. With CatWalk XT, you can extract a lot of information from just one footprint. In this post, I am taking it a step further by talking about the relationship between prints.
White lab rat
So what can one footprint tell you? Well, it could tell you a lot. Simply putting the paw in ink and studying the print left behind is one way to go about it, but there are far more sophisticated ways of footprint analysis.