Gait analysis system for rodents
Trusted by researchers around the world
Dr. Price: "I think the CatWalk is probably one of the most sophisticated pieces of equipment that I have seen."
NeuroPore Therapies (San Diego, California) does important research in the field of neurodegenerative disorders. Dr. Diana Price, Dr. Asma Khan and Robert Johnson are currently using CatWalk XT to study Parkinson’s disease.
Who uses CatWalk XT?
CatWalk XT gait analysis has been validated in research and experimental procedures for several (neurological) disorders and lesions. Examples include spinal cord injury and other nerve injuries, neuropathic pain, arthritis, stroke, Parkinson’s, Cerebellar ataxia, traumatic brain injury, peripheral nerve damage, and more.
It does not matter if gait is affected due to genetic, chemical or physical injury to the central nervous system, peripheral nervous system, or skeletal or muscle functioning. As long as your animal is able to traverse the CatWalk runway, you can evaluate its gait.
CatWalk XT is a complete highly sensitive tool to assess gait and locomotion. The footprints are captured while the rat or mouse voluntarily traverses a glass plate towards a goal box.
The system consists of:
- A corridor that directs the free movement of your subject in a straight line to facilitate learning and improve reproducibility
- A hardened glass walkway that enables CatWalk XT's Illuminated Footprints technology
- A high speed color camera for extremely accurate spatial and temporal resolution
- And the CatWalk XT software for the recording and automated analysis of the locomotor ability of your rodents
Advanced gait analysis
Due to the high temporal and spatial resolution of the color camera in combination with the Illuminated Footprints technology, the CatWalk XT software identifies subtle changes within the dimensions, position and timing of each footprint. Over 100 parameters are calculated for qualitative and quantitative analysis of individual footfalls and gait!
How does it work
The Automatic Footprint Classification Module takes the manual labor of classifying each footprint out of your hands, cutting your experiment time in half, while keeping you in control.
The Interactive Footprints Measurements module allows you to look in more detail at each footprint itself. You can measure toe spread, intermediate toe spread, and print length in order to calculate the Sciatic Functional Index. Furthermore, you can use it to measure the angle of the pawprint in relation to the body axis of the rodent.
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Getting the perfect run
CatWalk™ XT is a gait analysis system based on the voluntary movement of rats or mice across a corridor, over a glass plate. Generally, animals quickly learn to cross in a consistent manner, especially rats. However, familiarizing them with the system before you start your experiment makes your job a lot easier. So how do you familiarize and motivate your rats?
Kristina Ängeby Möller has a lot of experience with pain research and gait analysis in rats, and shares some tips and tricks!