Fear conditioning

The fear response is quickly learned and long remembered by rodents. It is therefore a powerful and robust behavior to use for investigating memory and fear in laboratory rodents. The fear responses most often measured in fear studies are freezing (watchful immobility) and the startle reflex. 

The fear conditioning setup from Noldus allows you to automatically and accurately measure both these behavioral responses during classical and contextual fear conditioning tests with rats or mice.

Accurate detection of freezing and startle behaviors

EthoVision XT tracking software does not only accurately track the center point, nose point, and tail base of your animal. It also simultaneously measures general activity in the entire arena. This is very useful when studying freezing behavior and so accurate that even the tiniest movement can be detected.

This video shows you how activity detection (freezing detection) in EthoVision XT works.

Data you can use

EthoVision XT automatically calculates parameters that are related to the movement of the animal and its body points, such as average distance moved and velocity. Additionally, activity detection is essential for fear conditioning research, and data is presented in four levels: inactive, moderately active, active, and highly active. For these levels, a minimal duration threshold can be set, and of course, the thresholds of the levels itself are user-defined.  

Interesting links