Mouse models are essential for neuroscience research. Many tests are susceptible to bias. Home cage testing provides a number of solutions.
Prof. Dr. Berry M. Spruijt recently retired from his position at Utrecht University. I had the honor of attending the symposium that was organized to reflect on and celebrate his career.
These studies specifically investigate the long-term effects of L-DOPA or levopoda, a common clinical treatment for Parkinson's disease, with which many patients struggle.
Traditional standard tests with rats or mice are carried out immediately after human interference. Therefore, the behavior of the animals may not be natural and spontaneous.
Here are six recommendations the authors list to improve the translational and predictive value of behavioral readouts.
Scientists have been performing open field tests for quite some time now. Over the years it has become one of the most popular tests in rodent behavioral research. So what’s not to love?
The most common psychiatric disorders are mood and anxiety related. However, the underlying mechanisms of these diseases are still largely unknown. This complicates the development of effective treatment and drugs.
The ability to recognize harmful situations and respond accurately is important for the survival of any animal. In order to respond to these situations the animal must be able to learn, remember, and alter its behavior.
Behavior of laboratory rodents is often studied in well-controlled, simple experiments, in an environment that is fundamentally different from the animal’s home cage.
To find out more about human and animal learning and memory, we might just have to go to sleep. Ahem – research on sleep, I mean.