gait-analysis-catwalk-xt

Gait analysis at the PSDL using CatWalk

Our lab studies the Neuronal Ceroid Lipofuscinoses (NCLs) or Batten disease, which are a group of progressive and genetically inherited neurodegenerative diseases that affect children and young adults.
male-mice-behavioral-studies

Why it doesn’t seem fair to prefer male mice in behavioral studies

Is it justified to use male mice only in behavioral studies, as many diseases affect men and women differently? This might be the most important argument to favor including female mice in certain studies.
ir-backlight-rodent-behavioral-testing

IR backlight in rodent behavioral testing

How do mice act in complete darkness? Ann-Kristina Fritz and her colleagues ordered a large, round open field with IR backlight, custom made by Noldus, to investigate.
new-mice-model-sporadic-alzheimers

Spatial and odor memory impaired mice – new model for Alzheimer’s

Plaques and tangles… those of you even remotely familiar with Alzheimer’s disease (AD) will immediately recognize these hallmarks. But they are linked to familial AD, while sporadic AD is far more common.
how-obese-mice-get-moving

How obese mice get moving

By a showing of hands: how many of you started this New Year with the resolution to get moving? Burn off those extra holiday calories, or finally really get in shape?
magnetogenetics

No science fiction: Magnetogenetics and how to induce animal behavior

Optogenetics has been invaluable in many brain studies, chemogenetics has been a good non-invasive alternative. Magnetogenetics is the new kid on the block. Can it do better?
assessing-motor-deficits-traumatic-brain-injury

Assessing motor deficits in mice following traumatic brain injury

Today Marcelle Cline and Donna Cross are so kind to share their insights on testing TBI mice with the CatWalk XT system.
serotonin-and-social-skills

Serotonin and social skills: how adult mice differ from juveniles

Serotonin is a busy neurotransmitter, influencing processes as memory, mood, emotion, appetite, and sexuality. A prime role for this neurotransmitter is social behavior, across a variety of species; humans, rodents, primates.
secret-social-role-ca2-hippocampus

Revealing the secret social role of the CA2 hippocampus

Aggressive behavior is adaptive for most species. But how is this aggressive behavior mediated in the brain? A recent study indicates that the hippocampus is a crucial neural component in mediating social recognition.
mice-cerebellar-plasticity

How to really challenge mice cerebellar plasticity

Jan-Willem Potters used the ErasmusLadder in his thesis research to study the role of specific mutations of plasticity in the cerebellar microcircuit of mice.