mice-alzheimers-disease

Mice with Alzheimer’s disease walk well but remember poorly

A large number of genetically engineered mouse models are available to study different aspects of Alzheimer’s disease.
circadian-rhythmicity-behavioral-studies

Circadian rhythmicity and other behavioral studies

Many labs use video tracking software to increase the efficiency of their research. In fact, EthoVision XT video tracking software has just reached an impressive milestone: 2000 sites worldwide.
high-throughput-phenotyping-home-cage

Testing without stress: high-throughput phenotyping

The ability to recognize harmful situations and respond accurately is important for the survival of any animal. In order to respond to these situations the animal must be able to learn, remember, and alter its behavior.
cognitive-impairment-cranial-radiation

Connects some dots - cognitive impairment and cranial radiation

On a yearly basis, an estimated 20.000 individuals are diagnosed with primary brain tumors in the United States alone. About ten times that number of patients will receive treatment for primary or metastatic brain cancer.
object-recognition-automated-video-tracking

How to get reliable results on object recognition using video tracking

In the beginning of this year I wrote a post about the Morris water maze test, a popular and well-validated paradigm to study learning and memory in rats and mice.
home-cage-testing

Why it is smart to test your animal in its home cage

Behavior of laboratory rodents is often studied in well-controlled, simple experiments, in an environment that is fundamentally different from the animal’s home cage.
optogenetics-and-operant-conditioning

Optogenetics and operant conditioning

A great example of optogenetics in behavioral studies is the work of Dr. Kravitz and Dr. Kreitzer at the Kreitzer lab (currently, Kravitz works at the NIDDK in Bethesda). Let me tell you about it.
optogenetics

Optogenetics - Shining a light on brains and behavior

Brains are complicated. We all know that. Like an entangled bunch of wires. Still, over the years, neuroscientists have been able to map out several brain regions and their functions in behavior and physiology.
drunken-mice-get-aggressive-alzheimers-drugs

Drunken mice get aggressive on Alzheimer’s drugs

Will there ever be a cure for alcoholism? Well, some laboratory studies show that certain drugs might stop the cravings. But they might also cause serious side-effects such as aggressive behavior.
temporal-gait-parameters

Time is of the essence - how you can use it in gait analysis

I have written two blog posts about static gait parameters. Now it’s time to talk about all four paws, and the time based relationships between them. If you ask me, we’ve been saving the best blog post for last!