No two mice alike: leveraging inter-individual variability in threat conditioning of inbred mice to model trait anxiety

brown mouse on a rope

Dr. Kovlyagina and her collaborators have developed a novel experimental and computational pipeline to operationalize trait anxiety in male and female inbred (C57BL6J) mice. For this webinar Dr. Kovlyagina will provide insight into the methodology of their pipeline and how EthoVision XT contributed to it.

Date | Thursday, 11 April 2024

Time | 4pm CEST / 10am EDT

Duration | 60 minutes



Personality and trait research in humans has identified trait anxiety as a major risk factor for developing mood and anxiety disorders. Traits, defined as consistent behavioral patterns within an individual across various contexts, necessitate evaluation through diverse tasks for effective classification. Dr. Kovlyagina and her co-authors developed a novel pipeline by combining the threat conditioning paradigm with prolonged retrieval session and classical anxiety tasks to elucidate a behavioral marker of trait anxiety in inbred mice. The resulting experimental and computational pipelines are designed to be easily adopted and utilize a mix of commercial and open-source solutions.


Dr. Irina Kovlyagina

Dr. Kovlyagina completed work on her doctoral thesis last year in the laboratory of Prof. Beat Lutz at Johannes Gutenberg University in Mainz, Germany. Her research focused on establishing a high throughput, translationally relevant model of trait anxiety.

Her previous experience includes development and characterization of ALS models at Johns Hopkins University and the University of Maryland in Baltimore, USA

Irina Kovlyagina

Huib van den Heuvel

Huib van den Heuvel

Huib van den Heuvel received his Masters in Animal Sciences at the University of Wageningen, The Netherlands. He specialized in animal behavior and specifically the use of sensors in quantifying behavior of chickens. 

After his studies, Huib came to work at the marketing department of Noldus IT. Here he is responsible for writing and conceptualizing marketing materials for the animal market and especially PhenoTyper and CatWalk XT. 



11th April 2024
virtual event


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