ErasmusLadder is an asset to your lab because it can quickly determine if your mice have motor learning and performance deficits, like no other test can. On this page are 8 main reasons to back this up. Or, read what researchers have to say about it in this review article:
Sathyanesan, A.; Gallo, V. (2018). Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective. Neurobiology of learning and memory, doi: 10.1016/j.nlm.2018.04.016.
- ErasmusLadder is the only commercially available system for fully-automated testing motor learning and motor function in laboratory mice.
- It integrates measuring locomotor performance (gait, coordination) and associative, adaptive, and conditioned learning.
- It is a unique tool to non-invasively test cerebellar functioning.
- The standardized protocol was designed, validated, and published by the Erasmus MC (Rotterdam, The Netherlands).
- You can adjust the protocol, so it can detect cerebellar phenotypes, so it is useful in ataxia research, autism research, and much more. This also allows for the analysis of possible confounding variables.
- It is easy to use, requiring hardly any training and animal handling skills.
- Motivating cues (air and light) help in getting consistent runs.
- The paradigm is easy, even severely ataxic mice quickly learn to traverse the ladder. Trials are sufficiently challenging for controls, but not too challenging for experimental groups. This way all mice are able to undergo testing and detailed results are gathered during each run.
- Trials take place in two phases. The second phase includes obstacle trails: the animal is presented with a challenge for which it needs proper cerebellar functioning. In order for this test to work, this challenge needs to be precise, and tuned to the individual and the way it is behaving in that specific run. And that is exactly what the ErasmusLadder does.
- Analysis occurs on-the-fly and without having to create profiles. Just click ‘calculate’!