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| CatWalk is used at academic research institutes, universities, and pharmaceutical companies. The system has been used in many scientific studies of which you can find the publications below. | Neurotrauma |
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Deumens, R.; Koopmans, G.C.; Honig, W.M.M.; Maquet, V.; Jerome, R.; Steinbusch, H.W.M.; Joosten, E.A.J (2006). Chronically injured corticospinal axons do not cross large spinal lesion gaps after a multifactorial transplantation strategy using olfactory ensheathing cell/olfactory nerve fibro-blast-biomatrix bridges. Journal of Neuroscience Research, 3, 811-820.
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Gensel, J.C.; Tovar, C.A.; Hamers, F.P.T.; Deibert, R.J.; Beattie, M.S.; Bresnahan, J.C. (2006). Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. Journal of Neurotrauma, 23, 36-54.
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Hamers, F.P.T.; Koopmans, G.C.; Joosten, E.A.J. (2006). Catwalk-assisted gait analysis in the assessment of spinal cord injury. Journal of Neurotrauma, 23, 537-548.
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Hamers, F.P.T.; Lankhorst, A.J.; van Laar, T.J.; Veldhuis, W.B.; Gispen, W.H. (2001). Automated quantitative gait analysis during overground locomotion in the rat: Its application to spinal cord contusion and transection injuries. Journal of Neurotrauma, 18, 187-201.
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Hendricks, W.T.J.; Eggers, R.; Ruitenberg, Marc J.; Blits, B.; Hamers, F.P.T.; Verhaggen, J.; Boer, G.J. (2006). Profound differences in spontaneous long-term functional recovery after denied spinal tract lesions in the rat. Journal of Neurotrauma, 23, 18-35.
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Jakeman, L.B.; Chen, Y.; Lucin, K.M.; McTigue, D.M. (2006). Mice lacking L1 cell adhesion molecule have deficits in locomotion and exhibit enhanced corticospinal tract sprouting following mild contusion injury to the spinal cord. European journal of Neuroscience, 23, 1997-2011.
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Joosten, E.A.; Veldhuis, W.B.; Hamers, F.P. (2004). Collagen containing neonatal astrocytes stimulates regrowth of injured fibers and promotes modest locomotor recovery after spinal cord injury. Journal of Neuroscience Research, 77, 127-142.
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Klapka, N.; Hermanns, S.; Straten, G.; Masanneck, C.; Duis, S.; Hamers, F.P.T.; Müller, D.; Zuschratter, W.; Müller, H.W. (2005). Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. European Journal of Neuroscience, 22, 3047-3058.
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Kloos, D.K.; Fisher, L.C.; Detloff, M.R.; Hassenzahl, D.L.; Basso, M.B. (2005). Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Experimental Neurology, 191, 251-265.
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Koopmans, G.C.; Brans, M.; Gómez-Pinilla, F.; Duis, S.; Gispen, W.H.; Torres-Aleman, I.; Joosten, E.A.J.; Hamers, F.P.T. (2006). Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions. European Journal of Neuroscience, 23, 1035-1046.
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Koopmans, G.C.; Deumens, R.; Honig, W.M.M.; Hamers, F.P.T.; Steinbusch, H.W.M.; Joosten, E.A.J. (2005). The assessment of locomotor function in spinal cord injured rats: The importance of objective analysis of coordination. Journal of Neurotrauma, 22, 214-225.
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Lankhorst, A.J.; ter Laak, M.P.; van Laar, T.J.; van Meeteren, N.L.U.; de Groot, J.C.M.J.; Schrama, L.H.; Hamers, F.P.T.; Gispen, W.H. (2001). Effects of enriched housing on functional recovery after spinal cord contusive injury in the adult rat. Journal of Neurotrauma, 18, 203-215.
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Liebscher, T.; Schnell, L.; Schnell, D.; Scholl, J.; Schneider, R.; Gullo, M.; Fouad, K.; Mir, A.; Rausch, M.; Kindler, D.; Hamers, F.P.; Schwab, M.E. (2005). Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Annals of Neurology, 58, 706-719.
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Meeteren, N.L.U. van; Eggers, R.; Lankhorst, A.J.; Gispen, W.H.; Hamers, F.P.T. (2003). Locomotor recovery after spinal cord contusion injury in rats is improved by spontaneous exercise. Journal of Neurotrauma, 20, 1029-1037.
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Starkey M.L., Barritt A.W., Yip P.K., Davies M., Hamers F.P., McMahon S.B., Bradbury E.J. (2005). Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice. Experimental Neurology, 195, 524-539.
 | Pain |
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Ängeby-Möller, K.; Berge, O.G.; Hamers, F.P.T. (2000). Locomotor behaviour in normal and monoarthritic rats assessed by a new computer assisted method. Abstr. Measuring Behavior 2000, 3rd International Conference on Methods and Techniques in Behavioral Research (Nijmegen, 15-18 August 2000), 8-10.
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Gabriel, A.F.; Marcus, M.; Honig, W.; Walenkamp, G.; Joosten, E. (2007). The CatWalk method: A detailed analysis of behavioral changes after acute inflammatory pain in the rat. Journal of Neuroscience Methods, 163, 9-16.
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Koopmans, G.C.; Gabriel, A.F.; Pragt, E.; Hamers, F.P.T.; Joosten, E.A.J. (2005). The 'CatWalk' automated quantitative gait analysis; a novel behavioral assay for the preclinical assessment of pain. Abstr. Measuring Behavior 2005, 5th International Conference on Methods and Techniques in Behavioral Research (Wageningen, 30 August - 2 September 2005).
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Vogelaar, C.F.; Vrinten, D.H.; Hoekman, M.F.; Brakkee, J.H.; Burbach, J.P.; Hamers, F.P. (2004). Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome. Brain Research, 1027, 67-72.
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Vrinten, D.H.; Hamers, F.P.T. (2003). 'CatWalk' automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat: a comparison with Von Frey testing. Pain, 109, 203-209.  | Parkinson |
- Vlamings, R.; Visser-Vandewalle, V.; Koopmans, G.; Joosten, E.A.J; Kozan, R.; Kaplan, S.; Steinbusch, H.W.M.; Temel, Y. (2007). High frequency stimulation of the subthalamic nucleus improves spreed of locomotion but impairs forelimb movement in Parkinsonian rats. Neuroscience, 148, 815-823.
| Stroke |
- Wang, Y.; Bontempi, B.; Hong, S.M.; Mehta, K.; Weinstein, P.R.; Abrams, G.M.; Liu, J. (2008). A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. Journal of Cerebral Blood Flow & Metabolism (online publication)
| Other |
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Deumens, R.; Jaken, R.J.; Marcus, M.A.; Joosten, E.A. (2007). The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection. Journal of Neuroscience Methods, 164, 120-130.
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Smidt, M. P., Smits, S. M., Bouwmeester, H., Hamers, F. P., van der Linden, A. J., Hellemons, A. J., Graw, J., and Burbach, J. P. (2004). Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development, 131, 1145–1155.
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Kistler W.M., De Jeu M.T.G., Elgersma Y., Van Der Giessen R.S., Hensbroek R., Luo C, Koekkoek S.K., Hoogenraad C.C., Hamers F.P., Gueldenagel M., Sohl G., Willecke K., De Zeeuw C.I. (2002). Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance. Annals of New York Academy of Sciences, 978, 391-404. | | |
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