There is still no cure for Parkinson’s. Recent studies have been focusing on neurorestoration. A recent study from Cronin and Grealy (Neuroscience, 2017) investigates several existing drugs, like Isradipine (used for high blood pressure), Minocycline (antibiotic), and Rasagiline (normally used in conjuction with PD drug Levodopa).
In order to test whether isradipine, minocycline, and rasagiline could protect or restore locomotor functioning after treatment with 6-OHDA (a well-known model for Parkinson’s), the zebrafish larvae were tested using DanioVision.
Individual larvae were placed in a 96-well plate, and their activity was measured during a 50-minute period at 5 days post fertilization, with 10-minute alternating light-dark cycles. The researchers used EthoVision XT to calculate mean distance moved per minute and total distance moved.
Researchers found that rasagiline restored locomotor function in 6-OHDA-treated zebrafish. It also restored dopaminergic neurons. Minocycline also restored locomotor function, but did not have the restorative effect in the brain. Isradipine showed no significant improvement in either area.
Cronin, A.; Grealy, M. (2017). Neuroprotective and Neuro-restorative Effects of Minocycline and Rasagiline in a Zebrafish 6-Hydroxydopamine Model of Parkinson’s Disease. Neuroscience, 367, 34-46.